Curcumin nanoparticles found to shorten TB

Innovation in Sciences and Technology Basic Sciences :Curcumin nanoparticles found to shorten TB treatment time.

Mains Paper 3: Science & Technology | Awareness in the fields of IT, Space, Computers, robotics, nano-technology, bio-technology and issues relating to intellectual property rights.

From UPSC perspective, following things are important:

Prelims level: Particulars of the TB disease and Isoniazid, name of the basic ingredient.

Mains level: If a question comes in mains on Nanotechnoolgy. This new use of Nano-particle could be quoted as an example.


What: Researchers have found that the basic ingredient of turmeric, when administered in a nanoparticle formulation has several favourable properties in the treatment of tuberculosis in mice
Name of the basic ingredient: Curcumin
The results were published in the journal Frontiers in Immunology

Results of the Research

During the research, regular curcumin was able to drastically reduce liver toxicity induced by TB drug isoniazid
Also, the treatment of TB with isoniazid along with 200 nanometre curcumin nanoparticles led to “dramatically reduced” risk of disease reactivation and reinfection
Because of the increased bioavailability of curcumin, the duration of treatment to achieve complete eradication of the bacteria is reduced significantly

Other positive effects of using ‘Curcumin’

Quite often, patients stop taking anti-TB drugs for a few days due to liver toxicity
Since the addition of curcumin reduces liver toxicity there can be better treatment and lesser risk of drug resistance emerging

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